This event aims to deepen our understanding as to how Smart Specialisation can be an effective tool to help territories recover from the current pandemic-induced crisis and discover new opportunities for more sustainable and inclusive economies. For this, we first need to understand what worked and what did not work in the previous programming period 2014-2020 and identify a set of sound recommendations for the Smart Specialisation of the next generation. This workshop offers a unique forum to practitioners, policy-makers and researchers for discussing concrete achievements, good practices, and challenges related to implementing the Smart Specialisation policy in EU regions, such as: